Diclofenac may increase the risk of miscarriage and malformations and should not be used during the first and second trimesters of pregnancy unless considered essential by your doctor.
Can a pregnant woman take diclofenac injection?
Conclusion: Our study suggests that the use of diclofenac is relatively safe during the first trimester of pregnancy and the studied sample size makes it possible to exclude a risk of congenital malformation higher than 3.3, with a power of 80%.
Which painkiller injection is safe in pregnancy?
Paracetamol – With its excellent safety profile, paracetamol is widely used as the first line pain relief drug treatment throughout pregnancy and during breast feeding. NSAIDS – Where possible women should avoid taking NSAIDs before 30 weeks of pregnancy.
Is diclofenac safe in 2nd trimester?
Second trimester diclofenac use was significantly associated with low birth weight (adjusted OR 3.1, 95% CI 1.1 to 9.0), whereas third trimester use was significantly associated with maternal vaginal bleeding (adjusted OR 1.8, 95% CI 1.1 to 3.0). No associations with other neonatal complications were found.
Is diclofenac injection safe?
The risk can happen within the first weeks of using diclofenac injection and may be greater with higher doses or long-term use. Do not use diclofenac injection right before or after bypass heart surgery. This medicine may raise the chance of severe and sometimes deadly stomach or bowel problems like ulcers or bleeding.
Why diclofenac is not given in pregnancy?
Premature closure of the ductus arteriosus
Taking diclofenac or another NSAID after 30 weeks of pregnancy can cause the ductus arteriosus to close while the baby is in the womb.
Why is diclofenac contraindicated in pregnancy?
Diclofenac Pregnancy Warnings
Administration of NSAIDs during the latter part of pregnancy may cause premature closure of the fetal ductus arteriosus, fetal renal impairment, inhibition of platelet aggregation, and delay labor and delivery.
Is Tramadol injection safe in pregnancy?
Using tramadol in pregnancy is not expected to cause problems that would require extra monitoring of your baby during pregnancy. However, women with some of the underlying conditions that tramadol can be used to treat might be more closely monitored to ensure that their baby is growing and developing as expected.
What medications are not safe during pregnancy?
What medicines should you avoid during pregnancy?
- Bismuth subsalicylate (such as Pepto-Bismol).
- Phenylephrine or pseudoephedrine, which are decongestants. …
- Cough and cold medicines that contain guaifenesin. …
- Pain medicines like aspirin and ibuprofen (such as Advil and Motrin) and naproxen (such as Aleve).
Why is ibuprofen not safe during pregnancy?
Pregnant women are advised to avoid ibuprofen during pregnancy, especially if they’re 30 or more weeks pregnant. Taking the medication at 30 weeks and beyond could cause premature closing of a baby’s ductus arteriosus.
What are the side effects of diclofenac?
Common side effects
- feeling dizzy or vertigo.
- stomach ache, wind or loss of appetite.
- feeling sick (nausea)
- being sick (vomiting) or diarrhoea.
- mild rash.
Can I take ibuprofen in 2nd trimester?
During weeks 14-27 (2nd trimester), you can take ibuprofen occasionally if you need medicine to relieve pain and reduce inflammation, but opt for paracetamol if possible.
Can a pregnant woman take feldene?
Feldene and Pregnancy
Feldene capsules are not recommended for use in pregnant women since safety has not been established in humans. Feldene should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. In late pregnancy, as with other NSAIDs, Feldene should be avoided.
Why diclofenac is not given IV?
The i.v. route has been used by others with few ill effects [1, 2]. Diclofenac is poorly water soluble, so that 1,2-propylene glycol is used as a solvent. The standard i.m. preparation also con- tains benzyl alcohol and mannitol.
How long does diclofenac injection last in the body?
Duration. – Maximum 2 days; change to oral treatment with an analgesic, e.g. ibuprofen or paracetamol, as soon as possible.
Does diclofenac cause weight gain?
Tell your doctor right away if any of these unlikely but serious side effects occur: swelling of the hands or feet (edema), sudden or unexplained weight gain, hearing changes (such as ringing in the ears), mental/mood changes, difficult/painful swallowing, unusual tiredness.