Is ondansetron safe in first trimester of pregnancy?

A new study from Brigham and Women’s Hospital finds that pregnant women taking the common anti-nausea medication ondansetron during the first trimester have no increased risk of cardiac malformations and only a slight increased risk of oral clefts.

Can I take ondansetron when pregnant?

Although not specifically approved by the FDA for the management of nausea and vomiting during pregnancy, ondansetron is now commonly used during pregnancy.

Can you take Zofran at 6 weeks pregnant?

New Study Says… A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus.

Can ondansetron cause miscarriage?

Currently, no scientific evidence has linked the anti-nausea drug Zofran, frequently prescribed “off-label” for morning sickness, to an increased risk of miscarriage.

What pregnancy category is ondansetron?

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

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Will taking Zofran hurt my baby?

If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small.

What nausea medicine is safe while pregnant?

In fact, the FDA has approved a prescription medication for use during pregnancy that is a combination of Vitamin B6 and Unisom. It is called Diclegis. This is the only FDA approved medication for treating nausea and vomiting during pregnancy.

Does Zofran really cause birth defects?

The results of these studies have concluded Zofran causes birth defects, particularly congenital heart defects, cleft palate defects, and kidney defects. The birth defects linked to use of Zofran during pregnancy include: 130% risk of overall birth defects. 620% risk of kidney obstruction birth defects.

How long does it take for Zofran to work for morning sickness?

Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran’s effects can last 8 to 12 hours. The Zofran dosage varies depending on the severity and cause of the nausea and vomiting.

Is Zofran used for anxiety?

Zofran (ondansetron) and Compazine (prochlorperazine) are prescribed for the treatment of nausea and vomiting. Zofran is often used to prevent and treat nausea and vomiting during chemotherapy and after surgery. Compazine is also used to treat psychotic disorders such as schizophrenia and anxiety.

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Does ondansetron cross the placenta?

Based on the findings of our analysis, ondansetron dosing does not need to be altered in pregnancy, and it readily crosses the placenta. However, a dosage adjustment is required in neonates because of its longer half-life, which is likely to be due to reduced clearance.

Can I take Zofran everyday while pregnant?

Taking Zofran while pregnant is low risk, and it has been prescribed for years for pregnancy nausea. That said, Zofran for pregnancy nausea is an off-label use, and there may be better options.

What are the side effects of ondansetron?

Ondansetron may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • constipation.
  • weakness.
  • tiredness.
  • chills.
  • drowsiness.

Does Zofran cause cleft palate?

Women suffering from extreme morning sickness often take Zofran (ondansetron) to combat their debilitating nausea and vomiting. However, two studies have found that the drug may increase risk of heart defects and cleft palate in children exposed in utero.

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